Plasmepsin II substrate

Molecular Weight: 1359.65
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO2)-Ser-Phe-Pro-Thr-OH
Sequence (1-letter): ALERTFF(NO2)SFPT-OH
Storage: -20 °C or below

Plasmepsin II is an aspartic acid protease produced by plasmodium parasites and related to human β-secretases. Plasmepsin II activity can be detected by the synthetic substrate ALERTFF(NO2)SFPT-OH through cleavage of the Phe-Phe(NO2) bond. The substrate cleavage re-action is monitored by the decrease in the average absorbance from 284 –324 nm.

Reference: Protein Science (1999), 8: 2001–2009.