Z-Arg-Arg-MbNA (Cathepsin B Substrate)

CAS Number: 100900-19-4
Molecular Weight: 619.32
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Z-Arg-Arg-4MbNA
Sequence (1-letter): Z-RR-4MbNA
Storage: -20 °C or below

Z-Arg-Arg-MbNA is a fluorogenic substrate for Cathepsin B. Cathepsin B is a lysosomal cysteine protease with a role in intracellular protein degradation. Cathepsin B crosses the blood-brain barrier and elevated levels are implicated in many neurological maladies including traumatic brain injury, epilepsy, and Alzheimer’s disease.

Activity is quantified by release of free fluorescent 4-Methoxy-β-naphthylamine (4MβNA) which excites at 335-350 nm and emits at 410-440 nm.