XY-4 (PPARγ agonist)

Product Number: L-1160

$170

XY-4 ((R)-1,1-difluoro-3-(phosphonooxy)propan-2-yl palmitate) is an analog of 2-palmitoyl lysophosphatidic acid (LPA) in which the sn-1 hydroxyl has been replaced by two fluorines. It acts as a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ) but does not stimulate LPA1, LPA2, or LPA3 receptors. PPARγ is a transcription factor of the nuclear receptor superfamily and has been implicated in atherogenesis.

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Lipids

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Lysophospholipid

CAS Number

474329-47-0

Molecular Formula

C19H37F2O6P

Molecular Weight (g/mol)

430.46

Purity

0.95

Storage

-20 °C or below

Shipping Temp

Gel Ice

Technical Data Sheet

1) Zhang, C., D. L. Baker, et al. (2004). “Lysophosphatidic Acid Induces Neointima Formation Through PPARgamma Activation.” The Journal of Experimental Medicine 199(6): 763-774.
2) McIntyre, T. M., A. V. Pontsler, et al. (2003). “Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.” Proceedings of the National Academy of Sciences 100(1): 131-136.

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