XY-4 ((R)-1,1-difluoro-3-(phosphonooxy)propan-2-yl palmitate) is an analog of 2-palmitoyl lysophosphatidic acid (LPA) in which the sn-1 hydroxyl has been replaced by two fluorines. It acts as a selective agonist of peroxisome proliferator-activated receptor γ (PPARγ) but does not stimulate LPA1, LPA2, or LPA3 receptors. PPARγ is a transcription factor of the nuclear receptor superfamily and has been implicated in atherogenesis.
XY-4 (PPARγ agonist)
|Molecular Weight (g/mol)||
-20 °C or below
1) Zhang, C., D. L. Baker, et al. (2004). “Lysophosphatidic Acid Induces Neointima Formation Through PPARgamma Activation.” The Journal of Experimental Medicine 199(6): 763-774.
2) McIntyre, T. M., A. V. Pontsler, et al. (2003). “Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.” Proceedings of the National Academy of Sciences 100(1): 131-136.