XY-14 (Lipid Phosphate Phosphatase 1 Inhibitor)

Product Number: L-9218


XY-14 is a competitive inhibitor of Lipid Phosphate Phosphatase 1 (LPP1) which is the major enzyme responsible for degrading lysophosphatidic acid (LPA) in platelets. XY-14 (10 μM) inhibits LPP1 in human pulmonary artery endothelial cells, preventing the dephosphorylation of sphingosine 1-phosphate (S1P) to sphingosine. XY-14 is also reported to inhibit LPP2 & LPP3 (1).


Biochemical Reagents


Inhibitor, Lysophosphatidic Acid, Phosphatidic Acid

CAS Number


Molecular Formula


Molecular Weight (g/mol)





-20 °C or below

Shipping Temp

Gel Ice

Technical Data Sheet

1) Smyth, S. S., V. A. Sciorra, et al. (2003). “Lipid Phosphate Phosphatases Regulate Lysophosphatidic Acid Production and Signaling in Platelets.” Journal of Biological Chemistry 278(44): 43214-43223.
2) Zhao, Y., S. K. Kalari, et al. (2007). “Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells: Role Of Lipid Phosphate Phosphatase-1 And Sphingosine Kinase 1.” J Biol Chem 282(19): 14165-77.
3) Lin, A., et al. (2017). “The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.” Nat Cell Biol 19(3): 238-251.
4) Langedijk, J. A. G. M., et al. (2021). “Inhibition of autotaxin by bile salts and bile salt-like molecules increases its expression by feedback regulation.” Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease 1867(11): 166239.

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