Vac14 Antibody, polyclonal



Vac14, also known as ArPIKfyve, is a scaffold protein that functions in a complex with PIKfyve and Sac3 (FIG4). This complex regulates the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) on endosomal membranes. Vac14 forms a pentamer at the membrane to facilitate assembly of the complex and binds a single copy each of PIKFYVE and Sac3. The coordinated lipid kinase and phosphatase activity within the complex maintains homeostasis of PI(3)P and PI(5)P and plays a role in the fusion and transport of endosomes.

Z-RV14 Vac14 antibody has been validated for WB, IP, and ICC and has been shown to recognize human and mouse/rat isoforms. The antibody was generated from a fusion protein with amino acids 523 to 782 of human Vac14.

Technical Data Sheet


Western, IP, ICC


Kinase, PI(3,5)P2


-80 °C or below

Shipping Temp

Dry Ice

D Sbrissa 1, O C Ikonomov, A Shisheva (1999) PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. JBC 30;274(31):21589-97

Sbrissa D et al. (2004) A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity. Mol Cell Biol 2004 Dec;24(23):10437-47

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