Urocortin, rat

CAS Number: 171543-83-2
Molecular Weight: 4704.52
Salt Form: TFA
Purity: >95%
Sequence (3-letter): Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2
Sequence (1-letter): DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Storage: -20 °C or below

Urocortin is closely related to corticotropin-releasing factor (CRF) and is widely expressed throughout the nervous system of mammals. Urocortin interacts with the CRF1 and CRF2 receptors and is important in stress-responses and appetite. Urotropin will cause an increase in heart rate and coronary blood flow through binding to CRF2 receptor and can prevent cardiac tissue damage from ischemic injury.

References
Kishimoto T, Pearse RV 2nd, Lin CR, Rosenfeld MG. A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle [published correction appears in Proc Natl Acad Sci U S A 1995 Apr 25;92(9):4074]. Proc Natl Acad Sci U S A. 1995;92(4):1108-1112. doi:10.1073/pnas.92.4.1108