Recombinant anti-Tks5 Nanobody, Clone # Nb77, COOH-terminal HA tag.
Type: VHH single domain
Source: E. Coli
Applications: ELISA, Immunoprecipitation, Pull down
Background: Tks5 VHH Antibody was produced in a llama with a recombinant fragment of the C-terminal SH3 domains then cloned for recombinant production in E. Coli. Tks5 (aka FISH, SH3PXD2A) is an 1105 amino acid protein with a N-terminal PX domain followed by five SH3 domains/interaction platforms. It is a substrate of Src kinase and is a component of cancer cell invadopodia and immune cell podosomes It is also involved in the degradation of the extracellular matrix by some cancer cells.
Recombinant anti-Tks5 Nanobody 77 was developed by Gulliver Biomed.
Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.
1) Beghein, E. et al. (2018). Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function. Sci Rep; 8:15606.
Keywords: Tks5, FISH, SH3PXD2A, nanobody, VHH, antibody, single domain
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