TACE Substrate (Fluorogenic)

Product Number: 860-78

$215.00$1,391.00

$215.00
$377.00
$1,391.00
SKU: 860-78 Category: Tags: ,

CAS Number: 396716-14-6
Molecular Weight: 1572.76
Salt Form: TFA
Purity: >95%
Sequence (3-letter): Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
Sequence (1-letter): Dabcyl-LAQAVRSSSR-EDANS
Storage: -20 °C or below

Dabcyl-LAQAVRSSSR-EDANS is a fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). TACE, also known as ADAM 17, cleaves TNF-α from the membrane to activate it. TACE cleaves the Ala-Val bond and the substrate can be used to screen for inhibitors.

Activity is quantified by release of fluorescent EDANS which excites at 365 nm and emits at 490 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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