TACE Substrate (Fluorogenic)

Product Number: 860-78


CAS Number: 396716-14-6
Molecular Weight: 1572.76
Salt Form: TFA
Purity: >95%
Sequence (3-letter): Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
Sequence (1-letter): Dabcyl-LAQAVRSSSR-EDANS
Storage: -20 °C or below

Dabcyl-LAQAVRSSSR-EDANS is a fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). TACE, also known as ADAM 17, cleaves TNF-α from the membrane to activate it. TACE cleaves the Ala-Val bond and the substrate can be used to screen for inhibitors.

Activity is quantified by release of fluorescent EDANS which excites at 365 nm and emits at 490 nm.




Caspase, Enzyme Substrates

Shipping Temp

Ambient Temperature


-20 °C or below

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