Suc-Ala-Leu-Pro-Phe-AMC (PPIase Substrate)

Product Number: 869-20

$79.00$150.00

$79.00
$150.00
SKU: 869-20 Category: Tag:

CAS Number: 142997-31-7
Molecular Weight: 702.31
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Suc-Ala-Leu-Pro-Phe-AMC
Sequence (1-letter): Suc-ALPF-AMC
Storage: -20 °C or below

Suc-ALPF-AMC is a fluorogenic substrate for peptidyl prolyl cis-trans isomerases (PPIases) including FK-506 binding proteins (FKBPs, also called macrophilins) and cyclophilins. PPIases, or rotamases, catalyze the cis-trans isomerisation of proline imidic peptide bonds to accelerate protein folding.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

References:

1) Ishikawa Y, Bächinger HP. A substrate preference for the rough endoplasmic reticulum resident protein FKBP22 during collagen biosynthesis. J Biol Chem. 2014 Jun 27;289(26):18189-201. doi: 10.1074/jbc.M114.561944.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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