CAS Number: 52299-14-6
Molecular Weight: 451.17
Salt Form: N/A
Sequence (3-letter): Suc-Ala-Ala-Ala-pNA
Sequence (1-letter): Suc-AAA-pNA
Storage: -20 °C or below
Solubility: DMSO >5 mg/mL, can be further diluted into neutral pH buffer
Suc-AAA-pNA is a sensitive substrate for human, rat leukocyte and porcine pancreatic elastases. Reactions are monitored by measuring an increase in the absorbance signal at 405-410 nm. Suc-AAA-pNA is also hydrolyzed by proteinase K, subtilisins and thermitase.
1. Lüdemann, J., Utecht, B. and Gross, W.L. (1990) “Anti-neutrophil cytoplasm antibodies in Wegener’s granulomatosis recognize an elastinolytic enzyme” J. Exp. Med. 171 (1): 357-362.
2. Böckle, B. Galunsky, B. and Müller, R. (1995) “Characterization of a keratinolytic serine proteinase from Streptomyces pactum DSM 40530” Appl. Environ. Microbiol. 61 (10): 3705-3710.
3. Chen, Z. et al. (1992) “Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis” 267: 18896-18901.