S1P Lyase Fluorogenic Substrate

Product Number: S-200U

$352.00$2,881.00

$352.00
$1,503.00
$2,881.00
SKU: S-200U- Category: Tags: , , ,

S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme.

Sphingosine-1-phosphate lyase (S1PL) cleaves sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy.


References

1. Billich, A., et al. (2013). “Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.” PLoS One 8(3): e59630.
2. Engel, N., et al. (2012). “Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A.” PLoS One 7(10): e47833.
3. Bedia, C., et al. (2009). “Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.” Chembiochem 10(5): 820-2.

Categories

Lipids

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Sphingolipid, Sphingosine 1-phosphate

CAS Number

1166838-84-1

Molecular Formula

C14H21N2O8P

Molecular Weight (g/mol)

376.3

Purity

95%

Storage

-20 °C or below, protect from light

Technical Data Sheet

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