Product Number: S-200U
S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme. [Read More...]
S1P Lyase Fluorogenic Substrate is designed for monitoring S1PL activity by releasing fluorescent 7-hydroxycoumarin in the presence of active enzyme.
Sphingosine-1-phosphate lyase (S1PL) cleaves sphingosine-1-phosphate into hexadecenal and phosphoethanolamine. S1PL has been proposed as a target for autoimmune disorder treatment and in cancer therapy.
| Categories | Lipids |
|---|---|
| Filter | Sphingolipid, Sphingosine 1-phosphate |
| CAS Number | 1166838-84-1 |
| Molecular Formula | C14H21N2O8P |
| Molecular Weight (g/mol) | 376.3 |
| Purity | 0.95 |
| Storage | -20 °C or below, protect from light |
| Shipping Temp | Dry ice or gel ice depending on destination |
1. Billich, A., et al. (2013). “Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.” PLoS One 8(3): e59630.
2. Engel, N., et al. (2012). “Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12A.” PLoS One 7(10): e47833.
3. Bedia, C., et al. (2009). “Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity.” Chembiochem 10(5): 820-2.
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