PPZ-A10

Product No: N-1410

$99
$189
$395

PPZ-A10 is an ionizable lipid used for formulating lipid nanoparticles to deliver RNA in vitro and in vivo. PPZ-A10 LNPs preferentially delivered Cre mRNA to liver and spleen immune cells when injected intravenously into mice at concentrations as low as 0.3 mg/kg. PPZ A10 LNPs containing RNA to generate chimeric antigen receptor macrophages were injected into a hepatocellular carcinoma mouse model resulting in decreased tumor burden and increased survival.

Categories

Lipids

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Ionizable/Cationic Lipids

CAS Number

2941268-67-1

Molecular Formula

C56H114N6O2

Molecular Weight (g/mol)

903.57

Purity

>95%

Shipping Temp

Ambient Temperature

Storage

-20 °C or below

Technical Data Sheet

1) H. Ni, Hatit, M.Z.C, et al. (2022) “Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo” Nat. Commun. 13:4766, 1-9, DOI: 10.1038/s41467-022-32281-5.
2) Z. Yang, Y. Liu, et al. (2023) “Dual mRNA co-delivery for in situ generation of phagocytosis-enhanced CAR macrophages augments hepatocellular carcinoma immunotherapy” J. Controlled Release, 360, 718-733, DOI: 10.1016/j.jconrel.2023.07.021.

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