PKC Isoenzyme Inhibitor / PKC(e) translocation peptide

Product Number: 880-15


Molecular Weight: 843.47
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH
Sequence (1-letter): EAVSLKPT-OH
Storage: -20 °C or below

Protein kinase C epsilon, PKC(e), is involved in the regulation of diverse cellular functions including neurotransmitter release in the brain. Translocation of PKC(e) is a marker of activity and can be blocked with isozyme specific peptides. Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH is a selective inhibitor of the translocation of PKC(e). It can be used to resolve the functions of PKC(e) from those of other PKC isozymes.


Obis et al. (2015) The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Molecular Brain (8)





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