PI(3,5)P2 diC8

Product Number: P-3508

$56
$265
$475

PI(3,5)P2 diC8 (Phosphatidylinositol 3,5-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,5)P2.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).


Product Keywords: Dioctanoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 (8:0/8:0), PI(3,5)P2 C8

Bulk discounts available, please email echelon@echelon-inc.com for information.

Publications

1. Marcus, S. L., M. R. Wenk, et al. (2001). “A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation.” FEBS Lett 494(3): 201-7
2. Johnson, L. M., K. M. James, et al. (2005). “Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity.” Biochemistry 44(9): 3432-3440.
3. Ikonomov, O. C., D. Sbrissa, et al. (2009). “Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.” J Biol Chem 284(36): 23961-71.
4. Silswal, N., et al. (2011). “Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.” Am J Physiol Heart Circ Physiol 300(6): H2016-2026.
5. Kirsch, S. A., et al. (2018). “Phosphatidylinositol-3, 5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2.” Cellular and Molecular Life Sciences: 1-13.

Categories

Lipids

Filter

diC8, Phosphoinositides, PI(3,5)P2

CAS Number

299216-96-9

Molecular Formula

C25H44Na5O19P3

Molecular Weight (g/mol)

856.48

Purity

>95%

Storage

-20 °C or below

Shipping Temp

Dry ice or gel ice depending on destination

Technical Data Sheet

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