PI(3,4)P2 diC4 (Phosphatidylinositol 3,4-bisphosphate diC4) is a synthetic, purified dibutanoyl PI(3,4)P2.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
Product Keywords: Dibutanoyl Phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4)P2 C4, PI(3,4)P2 C4, or PI34P2.
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1. Fernandes, F., et al. (2011). “Phosphoinositides direct equine infectious anemia virus gag trafficking and release.” Traffic 12(4): 438-451.
2. Stampoulis, P., T. Ueda, et al. (2012). “Atypical membrane-embedded PI(3,4)P2 binding site on p47phox PX domain revealed by NMR.” J Biol Chem(287): 17848-17859.