PI(3,4,5)P3 diC4

Product Number: P-3904

$59.00$484.00

$59.00
$272.00
$484.00

PI(3,4,5)P3 diC4 (Phosphatidylinositol 3,4,5-trisphosphate diC4) is a synthetic, purified dibutanoyl PI(3,4,5)P3.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.


Product Keywords: Dibutanoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (4:0/4:0), PI(3,4,5)P3 (4:0/4:0), or PIP3

Bulk discounts available, please email echelon@echelon-inc.com for information.

Publications

1. Thapar, R., A. E. Karnoub, et al. (2002). “Structural and biophysical insights into the role of the insert region in Rac1 function.” Biochemistry 41(12): 3875-83.
2. He, J., R. M. Haney, et al. (2008). “Molecular mechanism of membrane targeting by the GRP1 PH domainboxs.” J Lipid Res 49(8): 1807-15.
3. Lumb, C. N., J. He, et al. (2011). “Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.” Structure 19(9): 1338-46.
4. Agamasu, C., et al. (2016). “The Interplay Between Calmodulin and Membrane Interactions with the Pleckstrin Homology Domain of Akt.” The Journal of Biological Chemistry 292: 251-263.
5. Zhao, W., et al. (2019). “Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition.” Cell Res 29: 895-910.

Categories

Lipids

Filter

diC4, Phosphoinositides, PI(3,4,5)P3

Molecular Formula

C17H27Na7O22P4

Molecular Weight (g/mol)

868.21

Purity

>95%

Storage

-20 °C or below


Technical Data Sheet

You may also like…

  • PI(3,4,5)P3 diC8 (Phosphatidylinositol 3,4,5-trisphosphate diC8) - Echelon Biosciences
    Lipids

    PI(3,4,5)P3 diC8

    Product Number: P-3908

    $48.00$376.00 View products
  • PI(3,4,5)P3 diC16 (Phosphatidylinositol 3,4,5-trisphosphate diC16) - Echelon Biosciences
    Lipids

    PI(3,4,5)P3 diC16

    Product Number: P-3916

    $39.00$311.00 View products
  • PI(3,4,5)P3 (Phosphatidylinositol 3,4,5-trisphosphate) 18:0/20:4 - Echelon Biosciences
    Lipids

    PI(3,4,5)P3 18:0/20:4

    Product Number: P-3924

    $145.00$1,085.00 View products
  • PI(3,4,5)P3 (D-myo-Phosphatidylinositol 3,4,5-trisphosphate) 17:0/16:0 - Echelon Biosciences
    Lipids

    PI(3,4,5)P3 17:0/16:0

    Product Number: P-3917

    $56.00$467.00 View products
Scroll to Top