1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoethol (PAPEth) is a form of phosphaytidylethanol (PEth), which is formed primarily by transphosphatidylation of phosphatyidylcholine (PC) by phospholipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes, and is one of the longest-lived circulating EtOH metabolite yet identified. d5-PAPEth has fully deuterated ethanol headgroup and is an analog of one of five most abundant naturally occurring PEth species.
|Molecular Weight (g/mol)||
-20 °C or below
1) Lopez-Cruzan, M., et al. (2018). “Pharmacokinetics of Phosphatidylethanol 16:0/20:4 in Human Blood After Alcohol Intake.” Alcoholism: Clinical and Experimental Research 42(11): 2094-2099.
2) DiBattista, A., et al. (2022) “Quantitation of phosphatidylethanols in dried blood spots to determine rates of prenatal alcohol exposure in Ontario.” Alcoholism: Clinical and Experimental Research 46(2): 243-251.
3) Aboutara, N., et al. (2021). “Analysis of six different homologues of phosphatidylethanol from dried blood spots using liquid chromatography-tandem mass spectrometry.” Drug Test Anal 13(1): 140-147.
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