Orexin B, human

CAS Number: 205640-91-1
Molecular Weight: 2897.6
Salt Form: TFA
Purity: >95%
Sequence (3-letter): Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Sequence (1-letter): RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
Storage: -20 °C or below

Orexin A and Orexin B are neuropeptides produced in the lateral and posterior hypothalmus. They bind the OX1 and OX2 GPCRs which are involved in food uptake. Orexin A binds to OX1 & OX2 with equal affinity while Orexin B primarily binds to OX2. In addition the Orexins have been shown to have roles in wakefulness, mood, addiction, and lipid metabolism.

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