Oleoyl LPA, 18:1 LPA is a species of lysophosphatidic acid containing oleic acid at the sn-1 position and is the most potent LPA analog for calcium release. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
| Categories | Lipids |
|---|---|
| Filter | Lysophosphatidic Acid, Lysophospholipid |
| CAS Number | 22556-62-3 |
| Molecular Formula | C21H40O7NaP |
| Molecular Weight (g/mol) | 458.51 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Bagga, S., et al. (2004). “Lysophosphatidic acid accelerates the development of human mast cells.” Blood: 2004-2003-1166.
2) Khandoga, A. L., et al. (2010). “GPR92/LPA5 lysophosphatidate receptor mediates megakaryocytic cell shape change induced by human atherosclerotic plaques.” Cardiovasc Res 90(1): 157-156.
3) Kuwata, S., et al. (2013). “Extracellular lipid metabolism influences the survival of ovarian cancer cells.” Biochem Biophys Res Commun 439(2): 280-284.
4) Canul-Sánchez, J. A., et al. (2018). “Different agonists induce distinct single-channel conductance states in TRPV1 channels.” The Journal of General Physiology 150(12): 1735-1746.
5) Ledein, L., et al. (2020). “Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.” British Journal of Pharmacology 177(18): 4296-4309.
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