OC2-K3-E10

Product No: N-1210

$299
$505
$1,000

OC2-K3-E10 is an ionizable lipid for delivery of mRNA in lipid nanoparticles (LNPs). OC2-K3-E10 LNPs delivered Firefly luciferase mRNA when injected intramuscularly in mice and resulted in comparable levels of luminescence as SM-102 LNPs. LNPs were also able to deliver Cas9 mRNA and sgRNA into genetically modified mice. LNPs containing OC2-K3-E10 were able to encapsulate four-fold more mRNA copies per particle compared to SM-102.

Categories

Lipids

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Ionizable/Cationic Lipids

CAS Number

2933216-12-5

Molecular Formula

C54H111N5O7

Molecular Weight (g/mol)

942.51

Purity

>95%

Shipping Temp

Ambient Temperature

Storage

-20 °C or below

Technical Data Sheet

G. Tilstra, J. Couture-Senécal, et al. “Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery” Journal of the American Chemical Society 2023 145 (4), 2294-2304. DOI: 10.1021/jacs.2c10670.

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