MMP Inhibitor I

Product Number: 868-75


SKU: 868-75 Category: Tag:

CAS Number: 124168-73-6
Molecular Weight: 490.25
Salt Form: TFA
Purity: >96%
Sequence (3-letter): 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH
Sequence (1-letter): Abz-GPla-NHOH
Storage: -20 °C or below

4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH (FN439) is a inhibitor of matrix metalloproteinases. It inhibits interstitial and granulocyte collagenases (IC50 = 1 uM), granulocyte gelatinase (IC50 = 30 uM) and skin fibroblast stromelysin (IC50 = 150 uM) but not thermolysin and serine proteinases. It retains activity after incubation with pronase or human granulocyte elastase.

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