Lipid OA2 is an ionizable lipid which can form single component lipid nanoparticles (LNPs) for delivery of RNA. Similar to lipid-based transfection reagents like LipofectamineTM, pre-formed OA2 vesicles are incubated with RNA then the mixture is directly added cells. OA2 LNPs delivered siRNA to downregulate cytokine signaling 1 (SOCS1) in mouse bone marrow dentritic cells. These SOCS downregulated DCs were used as a vaccine which reduced tumor size in a B16-OVA mouse model.
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| Molecular Formula | C47H91Cl2N3O5 |
| Molecular Weight (g/mol) | 849.16 |
| Purity | >90% |
| Storage | -20 °C or below |
