Linolenoyl LPA, 18:3 is an LPA analog with an unsaturated acyl chain. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation, chemotaxis, platelet aggregation, wound healing, angiogenesis, tumor invasion, and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer, LPA primarily promotes cell survival, migration and invasion. May contain up to 5-10% of the 2-acyl isomer due to acyl transfer.
| Categories | Lipids |
|---|---|
| Filter | Lysophosphatidic Acid, Lysophospholipid |
| CAS Number | 68041-32-7 |
| Molecular Formula | C21H36NaO7P |
| Molecular Weight (g/mol) | 454.47 |
| Purity | >95% |
| Storage | -20 °C or below |
| Shipping Temp | Gel Ice |
1) sukahara, T., et al. (2006). “Different residues mediate recognition of 1-O-oleyllysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor gamma.” J Biol Chem 281(6): 3398-3407.
2) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
3) Reinartz, S., et al. (2019). “Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.” Molecular Oncology 13(2): 185-201.
4) Ledein, L., et al. (2020). “Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse.” British Journal of Pharmacology 177(18): 4296-4309.
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