CAS Number: 54784-44-0
Molecular Weight: 1206.35
Salt Form: TFA
Sequence (3-letter): Glp-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2
Sequence (1-letter): (Glp)fWSYaLRPG-NH2
Storage: -20 °C or below
LH-RH [D-Phe2, D-Ala6] is an analog of luteinizing hormone-releasing hormone, also known as Gonadotropin-releasing hormone (GnRH). LH-RH binds the gonadotropin releasing hormone receptor on gonadotrope cells in the pituitary gland, stimulating phospholipase C to release calcium and activating protein kinase C. It controls many functions including follicular growth, ovulation, corpus luteum maintenance in females, and spermatogenesis in males. The D-Phe2, D-Ala6 analog acts as a potent agonist and can induce ovulation and synchronize the reproductive cycle in Sprague-Dawley female rats.