Geranylgeranyl S-thiolodiphosphate (GGSPP) is an analog of GGPP in which the non-bridging oxygen has been replaced by sulfur resulting in a less-reactive compound.
| Categories | Biochemical Reagents |
|---|---|
| Filter | Isoprenoid Diphosphate |
| CAS Number | 373597-46-7 |
| Molecular Weight (g/mol) | 517.60 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Phan, R. M. and C. D. Poulter (2001). “Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors.” The Journal of Organic Chemistry 66(20): 6705.
2) Lin, F-Y., Liu, C-I., et al. (2010) “Mechanism of action and inhibition of dehydrosqualene synthase” Proc. Nat. Acad. Sci. USA 107(50), 21337-21342.
3) Tomita, T., Kim, S-Y. (2017) “Structural insights into the CotB2-catalyzed cyclization of geranylgeranyl diphosphate to the diterpene cyclooctat-9-en-7-ol” ACS Chem. Biol. 12(6), 1621-1628.
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