Galantide

Product Number: 471-02

$181.00$279.00

$181.00
$279.00
SKU: 471-02 Category: Tag:

CAS Number: 138579-66-5
Molecular Weight: 2198.1
Salt Form: TFA
Purity: >90%
Sequence (3-letter): Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence (1-letter): GWTLNSAGYLLGPQQFFGLM-NH2
Storage: -20 °C or below

Galantide is a chimeric peptide consisting of fragments of galanin and Substance P which acts as a reversible galanin receptor antagonist. The peptide antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets in a dose-dependant manner (IC50 = 1.0 nM). It antagonizes  the galanin-induced increase in K+ conductance IC50 = 4 nM).

References
1) Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188.
2) Mulvaney JM, et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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