Farnesyl Diphosphate (FPP)

Product Number: I-0150

Farnesyl Diphosphate (FPP) - Echelon Biosciences
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Trans,trans-farnesyl diphosphate (FPP) is an intermediate in isoprenoid biosynthesis. Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. FPP is formed by the condensation of DMAPP with two units of IPP catalyzed by farnesyl diphosphate synthase.

Provided as the tris-ammonium salt

Product Keywords: Farnesyl pyrophosphate, FPP, trans,trans-Farnesyl Diphosphate

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Categories

Biochemical Reagents
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Isoprenoid, Isoprenoid Diphosphate
CAS Number

104715-19-7
Molecular Formula

C15H37N3O7P2
Molecular Weight (g/mol)

433.42
Purity

>95%
Storage

-20 °C or below

Technical Data Sheet

1. Voynova, N. E., S. E. Rios, et al. (2004). “Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway.” J Bacteriol 186(1): 61-7.
2. Martin, D. M., J. Faldt, et al. (2004). “Functional Characterization of Nine Norway Spruce TPS Genes and Evolution of Gymnosperm Terpene Synthases of the TPS-d Subfamily.” Plant Physiol 135(4): 1908-1927.
3. Gibot, L., J. Follet, et al. (2009). “Human caspase 7 is positively controlled by SREBP-1 and SREBP-2.” Biochem J 420(3): 473-83.
4. Falara, V., Akhtar, T. A., Nguyen, T. T. H., Spyropoulou, E. A., Bleeker, P. M., Schauvinhold, I., … Pichersky, E. (2011). “The tomato terpene synthase gene family.” Plant Physiology, 157(2), 770-789. DOI: 10.1104/pp.111.179648
5. Sugimoto, H., et al. (2017). “Bioanalysis of farnesyl pyrophosphate in human plasma by high-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry and hybrid quadrupole Orbitrap high-resolution mass spectrometry.” Anal Bioanal Chem 409(14): 3551-3560.
6. Muchlinski, A., et al. (2019). “Biosynthesis and Emission of Stress-Induced Volatile Terpenes in Roots and Leaves of Switchgrass (Panicum virgatum L.).” Frontiers in Plant Science 10(1144).

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