PEG derivatized lipids are used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. The hydrophilic PEG chains decrease interactions with the reticular-endothelial system and increases the size of the particles both of which result in lowered clearance rate from the body. Incorporating mannose into DSPE-PEG2000 allows for targeting of LNPs to tumor cells.
L-2816
DSPE-PEG2000-Mannose
PEG derivatized lipids are used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. [Read More...]
