PEG derivatized lipids are used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. The hydrophilic PEG chains decrease interactions with the reticular-endothelial system and increases the size of the particles both of which result in lowered clearance rate from the body. The alkyne group of DSPE-PEG2000-Alkyne can be derivatized with an azide-containing molecule via a Cu-catalyzed “click” reaction allowing targeting of LNPs.
L-2812
DSPE-PEG2000-Alkyne
PEG derivatized lipids are used to increase the circulation time of liposomes and lipid nanoparticles (LNPs) in vivo. [Read More...]
