1,2-Dipalmitoyl-sn-glycero-3-phosphoserine, sodium salt (DPPS) is a form of phosphatidylserine (PS), a negatively charged phospholipid located in the inner leaflet of the cell membrane. During apoptosis PS is no longer restricted to the inner leaflet of the plasma membrane and migrates to the outer leaflet. Recognition of extra-leaflet PS by Anexin V is the basis of popular apoptosis assays. Similarly, during platelet activation, PS is translocated to the outer side where it facilitates assembly of the prothrombinase complex.
DPPS (16:0/16:0 PS)
|Molecular Weight (g/mol)||
4 °C or below
1) Qiao, K., et al. (2018). “Overexpression of Acyl-CoA-Binding Protein 1 (ChACBP1) From Saline-Alkali-Tolerant Chlorella sp. Enhances Stress Tolerance in Arabidopsis.” Frontiers in Plant Science 9(1772).
2) Yang, K.-J., et al. (2018). “Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy.” Biomaterials 171: 133-143.
3) Pye, V. E., et al. (2020). “A bipartite structural organization defines the SERINC family of HIV-1 restriction factors.” Nature Structural & Molecular Biology 27(1): 78-83.
4) Sivakumaren, S. C., et al. (2020). “Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.” Cell Chemical Biology 27(5): 525-537.e526.