DOPE-Lipoic Acid (S-DOPE) is a new helper lipid used to enhance RNA delivery and expression in LNP formulations. Incorporating S-DOPE into LNP formulations resulted in up to an 11-fold increase in mRNA transfection in vitro compared with standard LNPs. mRNA expression was enhanced in vivo resulting in lower doses being required to generate an immune response compared to conventional LNPs. S-DOPE is proposed to allow direct cytostolic RNA delivery, bypassing endosomal entrapment, by reaction with cell-surface thiols.
L-2310
DOPE-Lipoic Acid (S-DOPE)
DOPE-Lipoic Acid (S-DOPE) is a new helper lipid used to enhance RNA delivery and expression in LNP formulations. [Read More...]
