Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from dysregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. This analog is deuterated at the glycerol.
| Filter | Deuterated Lipids, Phosphoinositides, PI(3,4,5)P3 |
|---|---|
| Categories | Lipids |
| Molecular Formula | C41H73D5Na4O22P4 |
| Molecular Weight (g/mol) | 1143.94 |
| Purity | 95% |
| Storage | -20 °C or below |
