CL4H6

Product No: N-1016

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Harashima group from Hokkaido University developed a hepatocyte-specific drug delivery system called multifunctional envelope-type nanodevice (MEND) which gives improved siRNA endosomal escape efficiency. The three generations of the pH-responsive ionizable lipid of the MEND system are YSK05 (2012, pKa 6.4), YSK13 (2016, pKa 6.45), and CL4H6 (2019, pKa 6.25). The ED50 of Factor VII knockdown after the intravenous injection of YSK05, YSK13 and CL4H6 LNPs into mice were shown to be 60 ug/kg, 15 ug/kg, 2.5 ug/kg respectively.

Categories

Lipids

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Ionizable/Cationic Lipids

CAS Number

2256087-35-9

Molecular Formula

C59H113NO5

Molecular Weight (g/mol)

916.56

Purity

95%

Storage

-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

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