Harashima group from Hokkaido University developed a hepatocyte-specific drug delivery system called multifunctional envelope-type nanodevice (MEND) which gives improved siRNA endosomal escape efficiency. The three generations of the pH-responsive ionizable lipid of the MEND system are YSK05 (2012, pKa 6.4), YSK13 (2016, pKa 6.45), and CL4H6 (2019, pKa 6.25). The ED50 of Factor VII knockdown after the intravenous injection of YSK05, YSK13 and CL4H6 LNPs into mice were shown to be 60 ug/kg, 15 ug/kg, 2.5 ug/kg respectively.
Product No: N-1016
N-1016
CL4H6
Harashima group from Hokkaido University developed a hepatocyte-specific drug delivery system called multifunctional envelope-type nanodevice (MEND) which gives improved siRNA endosomal escape efficiency. [Read More...]
