Cathepsin L Inhibitor (RKLLW-NH2)

Product Number: 866-23

$96

CAS Number: 289480-71-3
Molecular Weight: 713.47
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Arg-Lys-Leu-Leu-Trp-NH2
Sequence (1-letter): RKLLW-NH2
Storage: -20 °C or below

Cathepsin L is a lysosomal cysteine protease with an important role in initiating protein degradation. Cathepsin L is also upregulated in several cancers and has been suggested as a drug target. In addition, extracellular secretion of Cathepsin L by tumors implicates it as a potential serum biomarker for  cancer progression. The inhibitor has a low micromolar IC50.

References:
1) A. Brinker, et al. (2000) “Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections” Eur. J. Biochem. 267, 5085-5092.

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