Pan-Akt VHH Antibody

Z-N001

$84.00$840.00

$84.00
$210.00
$840.00
SKU: Z-N001- Category: Tags: , ,

Recombinant anti-Akt Nanobody, Clone # Nb10, COOH-terminal HA tag.
Type: VHH single domain
Source: E. coli
Applications: ELISA, Immunoprecipitation, Pull down
Clonality: Monoclonal

Background: Pan-Akt VHH Antibody was produced in a llama with a recombinant full length Akt then cloned for recombinant production in E. coli cells. Akt kinases are three highly homologous (Akt 1, 2, 3) isoforms of serine/threonine kinases. Akt, also known as protein kinase b (PKB) is frequently over-activated in cancer and considered as a therapeutic target. However, most small molecule inhibitors lack sufficient specificity and to date there are no effective isoform-specific inhibitors available.

Recombinant anti-Akt Nanobody 10 was developed by Gulliver Biomed.


Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Merckaert, T. et al. (2020). Development and characterization of protein kinase B/AKT isoform-specific nanobodies. PLoS One. 15:e0240554.
2) Merckaert, T. et al. (2021). An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells.
Biomed Pharmacother. 133:111055.

Keywords: Akt, protein kinase b, PKB, nanobody, VHH, antibody


‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.

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