Ac-Val-Glu-Ile-Asp-pNA (Caspase 6 (Mch2) Substrate)

Product Number: 860-50

$94.00$344.00

$94.00
$344.00
SKU: 860-50 Category: Tags: ,

CAS Number: 189684-54-6
Molecular Weight: 636.28
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Ac-Val-Glu-Ile-Asp-pNA
Sequence (1-letter): Ac-VEID-pNA
Storage: -20 °C or below

Ac-Val-Glu-Ile-Asp-pNA is a colorimetric substrate for Caspase 6. Caspase 6 (Mch2) is a cysteine protease involved in the execution phase of apoptosis, mediating neuronal shrinkage. In addition, it has important roles in neurodegenerative disorders such as Huntington’s, Parkinson’s, and Alzheimer’s diseases. Caspase 6 cleaves the mutated huntintin protein and the amyloid precursor protein resulting in the aggregating protein fragments typical of Huntington’s and Alzheimer’s diseases respectively.

Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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