CAS Number: 319494-39-8
Molecular Weight: 500.25
Salt Form: N/A
Sequence (3-letter): Ac-Val-Glu-Ile-Asp-CHO
Sequence (1-letter): Ac-VEID-CHO
Storage: -20 °C or below
Ac-Val-Glu-Ile-Asp-CHO is a selective, reversible inhibitor of Caspase 6. Caspase 6 (MCH-2) is a cysteine protease involved in the execution phase of apoptosis, mediating neuronal shrinkage. In addition, it has important roles in neurodegenerative disorders such as Huntington’s, Parkinson’s, and Alzheimer’s diseases. Caspase 6 cleaves the mutated huntintin protein and the amyloid precursor protein resulting in the aggregating protein fragments typical of Huntington’s and Alzheimer’s diseases respectively.