Ac-Val-Asp-Val-Ala-Asp-AFC (Caspase 2 (ICH-1) Substrate)

Product Number: 863-48

$150.00$573.00

$150.00
$573.00
SKU: 863-48 Category: Tags: ,

CAS Number: 219137-85-6
Molecular Weight: 770.27
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Ac-Val-Asp-Val-Ala-Asp-AFC
Sequence (1-letter): Ac-VDVAD-AFC
Storage: -20 °C or below

Ac-Val-Asp-Val-Ala-Asp-AFC is a fluorogenic substrate for caspase 2. Caspase 2, part of the ICH-1 sub-family, is a cysteine protease with a poorly defined role in apoptosis. It associates with several apoptotic proteins such as death effector filament-forming Ced-4-like apoptosis protein (DEFCAP), RIP-associated Ich-1/Ced-3-homologue protein with a death domain (RAIDD), and apoptosis repressor with caspase recruitment domain (ARC). Caspase 2 can be activated by the PIDDosome formed by the association of PIDD1 and CRADD. Recent work demonstrates that Caspase-2 resides in the mitochondria and is essential for stress-induced apoptosis. Caspase-2 cleaves at an Asp residue with a preferred sequence of Val-Asp-Val-Ala-Asp-X.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

Categories

Peptides

Filter

Caspase, Enzyme Substrates

Shopping Cart
Scroll to Top