CAS Number: 143313-51-3
Molecular Weight: 492.22
Salt Form: N/A
Sequence (3-letter): Ac-Tyr-Val-Ala-Asp-CHO
Sequence (1-letter): Ac-YVAD-CHO
Storage: -20 °C or below
Solubility: DMSO (5 mg/ml), water (5 mg/ml), ethanol (30 mg/ml), DMF (30 mg/ml)
N-Ac-Tyr-Val-Ala-Asp-CHO (Ac-YVAD-CHO) is a synthetic peptide that reversibly and selectively inhibits interleukin-1β converting enzyme (ICE; Caspase-1). Caspase-1 is a pro-inflammatory cytokine and like other caspase inhibitors, interferes with the initiation of apoptosis and has numerous possible clinical applications
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2.Thornberry N.A. et al. (1992) “A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes” Nature 356: 768–774.