Ac-Trp-Glu-Ala-Asp-pNA (Caspase 1 (ICE) Substrate)

Product Number: 860-63

$99.00$361.00

$99.00
$361.00
SKU: 860-63 Category: Tags: ,

Molecular Weight: 681.24
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Ac-Trp-Glu-Ala-Asp-pNA
Sequence (1-letter): Ac-WEAD-pNA
Storage: -20 °C or below

Ac-Trp-Glu-Ala-Asp-pNA is a colorimetric substrate for Caspase 1. Caspase 1/Interleukin 1b converting enzyme (ICE) is a cysteine protease that cleaves specifically at aspartic acid. ICE converts inactive IL-1 beta precursor to a pro-inflammatory cytokine that mediates a wide range of immune and inflammatory response. ICE-related cysteine proteases are required for E1A-induced, p53-dependent apoptosis in baby rat kidney (BRK) cells. Adenovirus E1B 19K protein, which is a potent inhibitor of apoptosis, inhibits activation of these proteases in BRK cells.

Activity is quantified by the release of p-nitroaniline which is measured by absorbance at 405 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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