Ac-Ile-Glu-Pro-Asp-AMC (Caspase 8/Granzyme B Substrate)

Product Number: 860-69

$137.00$511.00

$137.00
$511.00
SKU: 860-69 Category: Tags: ,

CAS Number: 216757-33-4
Molecular Weight: 671.28
Salt Form: N/A
Purity: >96%
Sequence (3-letter): Ac-Ile-Glu-Pro-Asp-AMC
Sequence (1-letter): Ac-IEPD-AMC
Storage: -20 °C or below

Ac-Ile-Glu-Pro-Asp-AMC is a fluorogenic substrate for caspase-8 and granzyme B. Caspase 8 is a cysteine protease involved in apoptosis induced by Fas and other stimuli. It is an attractive therapeutic target for a variety of degenerative disorders. Granzyme B is a serine protease found in cytotoxic T-cells and NK cells. It cleaves and activates a number of caspases involved in apoptosis.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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