Ac-Arg-Gly-Phe-Phe-Pro-AMC

Product Number: 877-06

$158.00

$158.00
SKU: 877-06 Category: Tag:

Molecular Weight: 821.94
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Ac-Arg-Gly-Phe-Phe-Pro-AMC
Sequence (1-letter): Ac-RGFFP-AMC
Storage: -20 °C or below

Ac-Arg-Gly-Phe-Phe-Pro-AMC is a fluorogenic substrate suitable for the assay of cathepsin D. Cathepsin D cleaves the Phe-Phe bond and the resulting RP-AMC dipeptide can be cleaved by dipeptidyl peptidase IV (DPP IV) resulting in a fluorescent signal. Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.

Cathepsin D is a lysosomal aspartyl protease whose role is to degrade and activate intracellular proteins including hormones, enzyme precursors, and growth factors. Over expression in tumors stimulates metastasis and considered a marker of poor prognosis in breast cancer.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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