Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPARγ. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.
1. P.S. Baker et al “Fatty Acid Transduction of Nitric Oxide signaling” Journal of Biological Chemistry, 2005, 280, 42464-42475;
2. F.J. Schopfer et al “Covalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acid” Journal of Biological Chemistry, 2010, 285, 12321-12333.