6-O-palmitoyl-L-ascorbic acid (HAse Inhibitor)

Product Number: B-0601

$29.00$114.00

$29.00
$114.00

Hyaluronidases (HAse) are a group of enzymes that degrade Hyaluronan (HA), a linear polysaccharide comprised of a repeating disaccharide of N-acetylglucosamine and D-glucuronic acid. HA is involved in many biological processes including structural support, cell migration and tissue turnover. Hyaluronidases are involved in several pathological processes such as bacterial pathogenesis, the spreading of toxins/venoms and cancer progression, making hyaluronidases a potential pharmacological target. 6-O-Palmitoyl-L-ascorbic acid (Vcpal) is a micromolar HAse inhibitor of both bacterial and mammalian hyaluronidases and it is particularly selective for the Streptococcus agalactiae enzyme.

References

1) A. Botzki, et al. L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-ray structure and molecular modeling of enzyme-inhibitor complexes. J. Biol. Chem., 2004, 279, 45990-45997.

2) Spickenreither, M. et al. Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases. Bioorg. Med. Chem. Lett., 2006, 16, 5313-5316.


Categories

Biochemical Reagents

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Activity, Hyaluronic Acid, Inhibitor

CAS Number

137-66-6

Molecular Formula

C22H38O7

Molecular Weight (g/mol)

414.53

Purity

>95%

Storage

Room temperature

Technical Data Sheet

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