4A3-SCC-PH

Product No: N-1432

$275
$425
$725
$1,875

The linker-degradable ionizable lipids (LDIL) 4A3-SCC-PH and 4A3-SCC-10 (Echelon Catalog # N-1430) possess superior endosomal escape and rapid mRNA release abilities thanks to their unique GSH-responsive cone-shaped architecture. Lipid nanoparticles (LNPs) of 4A3-SCC-PH showed improved mCherry mRNA delivery in livers by 176-fold compared to DLin-MC3-DMA in vivo. 4A3-SCC-PH and 4A3-SCC-10 also demonstrated improved mRNA delivery in vivo, compared to their parent counterpart without a disulfide bond or control counterpart with a disulfide bond in the tail.

Categories

Lipids

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Ionizable/Cationic Lipids

Molecular Formula

C91H171N3O16S12

Molecular Weight (g/mol)

1948.09

Shipping Temp

Ambient Temperature

Storage

-20 °C or below

Technical Data Sheet

Chen Z. et al. ” Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo.” J. Am. Chem. Soc. 2023, 145(44) 24302-24314. doi: 10.1021/jacs.3c09143.

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