PF-8380 is a potent autotaxin (ATX) inhibitor (IC50 2.8 nM/101 nM purified enzyme/whole blood). Excessive activity of ATX is associated with numerous inflammatory conditions, cancers and other disease. Lysophosphatidic acid (LPA) produced by ATX stimulates cell proliferation through G-protein coupled receptorsLPA1-4. PF-8380 is orally bioavailable and effectively inhibits ATX in vivo reducing LPA levels in serum and at the site of inflammation in a rat arthritis model. Can delivered orally with the “Oral Formulation Vehicle”.

References

Gierse, J. et al (2010) “A Novel Autotaxin Inhibitor Reduces Lysophosphatidic Acid Levels in Plasma and the Site of Inflammation”> Journal of Pharmacology and Experimental Therapeutics 334(1):310.

Categories	Biochemical Reagents
Filter	Autotaxin, Inhibitor
CAS Number	1144035-53-9
Molecular Formula	C22H21Cl2N3O5
Molecular Weight (g/mol)	478.33
Purity	>97%
Storage	4 °C or below
Shipping Temp	Ambient Temperature

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1 mg (B-0702) quantity	1 mg (B-0702)	$56
10 mg (B-0702) quantity	10 mg (B-0702)	$201

PF-8380 (Autotaxin Inhibitor)

References

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PF-8380 (Autotaxin Inhibitor)

References

Related Products

1-Methylhistamine dihydrochloride

ATX-Red AR-2

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