PKC Isoenzyme Inhibitor / PKC(e) translocation peptide
…of the translocation of PKC(e). It can be used to resolve the functions of PKC(e) from those of other PKC isozymes. References Obis et al. (2015) The novel protein kinase…
…of the translocation of PKC(e). It can be used to resolve the functions of PKC(e) from those of other PKC isozymes. References Obis et al. (2015) The novel protein kinase…
…version of an octapeptide PKC(e) inhibitor (Cat# 880-15). Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH is a selective inhibitor of the translocation of PKC(e). It can be used to resolve the functions of PKC(e) from those…
Molecular Weight: 1053.67 Salt Form: TFA Purity: >95% Sequence (3-letter): Myristoyl-Leu-Ser-Glu-Thr-Lys-Pro-Ala-Val-OH Sequence (1-letter): (Myristoyl)LSETKPAV-OH Storage: -20 °C or below Protein kinase C epsilon, PKC(e), is involved in the regulation of…
Molecular Weight: 1928.4 Salt Form: TFA Purity: >96% Sequence (3-letter): Myristoyl-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH Sequence (1-letter): (Myristoyl)SIYRRGARRWRKL-OH Storage: -20 °C or below PKC Pseudosubstrate Inhibitor is a myristoylated, reversible, cell-permeable inhibitor of protein…
…residues as a signaling mechanism. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). PKC therefore plays an important role…
…PKCα, PKCε, and PKCδ and also competitively binds to the Ras activator RasGRP. 1,2-Diacylglycerols are formed in cells through the hydrolysis of phosphatidylinositol 4,5-bisphosphate by Phospholipase C. DAGs activate Protein…
…below RFARKGSLRQKNV(OH) is derived from the PKC pseudosubstrate sequence with the Ala at position 25 changed to Ser making it a substrate (Km=0.2 µM) for PKC rather than an inhibitor….
…is a synthetic peptide recognized as a substrate by Ca²⁺ calmodulin-dependent protein kinase II and Ca²⁺ phospholipid-dependent protein kinase (PKC). The sequence is homologous to phosphorylation site 2 on glycogen…
…as an allosteric activator of protein kinase C (PKC). The alpha isoform is a type I DGKs, slightly different calcium-responsiveness. Storage Store at 4 °C for up to 30 days….
…as an allosteric activator of protein kinase C (PKC). Research shows the zeta isoform of DGK undergoes tissue-specific alternative splicing resulting in an elongated N terminus enzyme predominantly in muscle….