Z-Phe-Tyr-CHO (Cathepsin L Inhibitor)

Product Number: 866-28


CAS Number: 167498-29-5
Molecular Weight: 446.18
Salt Form: N/A
Purity: >95%
Sequence (3-letter): Z-Phe-Tyr-CHO
Sequence (1-letter): Z-FY-CHO
Storage: -20 °C or below

Z-Phe-Tyr-CHO is a reversible peptidyl aldehyde inhibitor of Cathepsin L (IC50=0.85 nM).  It is selective vs cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Cathepsin L is a lysosomal cysteine protease with an important role in initiating protein degradation. Cathepsin L is also upregulated in several cancers and has been suggested as a drug target. In addition, extracellular secretion of Cathepsin L by tumors implicates it as a potential serum biomarker for cancer progression.





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